Bioinformatics Jobs

The Computational Scientist will provide analysis and develop algorithms and software for Professor Wenyi Wang's lab in the Department of Bioinformatics and Computational Biology. Dr. Wang's laboratory performs research aiming to gain new knowledge in the evolution of the human genome as well as the cancer genome. JOB SPECIFIC COMPETENCIES... Pipeline maintanence: Maintains and develops bulk and single-cell DNA, RNA data processing pipelines.. Protocol and agreement management: Maintains and develops research protocols and data access agreements. Software development: Maintains and further develops the lab's software packages, in collaboration with students and postdocs in the lab. Sequencing data analysis: Performs single cell and bulk sequencing data analysis, including data QC and initial processing, for data generated by in-house and by large-scale consortia. Computing management: Manages software and data stored on the lab's partition on the institute's high-performance computing infrastructure. EDUCATION: Required: Bachelor's degree in Biomedical Engineering, Electrical Engineering, Physics, Applied Mathematics or related field. EXPERIENCE: Required: Five years experience in scientific software development/analysis. With Master's degree, three years experience required. With PhD, one year of experience required. It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html Additional Information • Requisition ID: 151751 • Employment Status: Full-Time • Employee Status: Regular • Work Week: Days • Minimum Salary: US Dollar (USD) 81,000 • Midpoint Salary: US Dollar (USD) 101,500 • Maximum Salary : US Dollar (USD) 122,000 • FLSA: exempt and not eligible for overtime pay • Fund Type: Soft • Work Location: Hybrid Onsite/Remote • Pivotal Position: Yes • Science Jobs: Yes

As part of the new, ambitious, Data Science initiative at MDACC, we are establishing an innovative AI-augmented, Adaptive, Drug Discovery and Development computational Platform to accelerate the discovery and impact of novel therapies for cancer. The Platform will be intelligent and ever-learning. The Platform will enable novel opportunities for optimized therapies for patients with focus on rare... and hard-to-treat cancers through development of novel machine learning and Al technologies. The primary purpose of this Computational Scientist (Bioinformatics) is to carry out data preparation responsibilities; develop skilled bioinformatics and statistical programs; perform statistical analysis; and prepare written reports, manuscripts, and grant applications with investigators; working closely with the team and collaborators to discover novel therapeutic opportunities for cancer patients. Job Compentencies: • Bioinformatics tools and pipelines especially for Whole Genome /Exome sequencing, RNAseq, ideally for both bulk and Single Cell Analysis • Developing bioinformatics pipelines and analysis tools • Unix, R/Matlab, Python • Gene Set Enrichment and pathway analyses • Whole Genome /Exome sequencing, RNAseq data analysis from raw data including evaluating outputs, optimizing parameters and summarizing findings • Results interpretation (variant calling, functional annotation) • Data visualization and biological interpretation • Produce output for scientific publications and co-author said publications • Data clean-up and QC of biological sequencing data • Running bioinformatics pipelines on high performance computing. Other duties as assigned. Service Orientation: 1. Conduct research and interactions with colleagues in a reliable, responsive, safe, friendly and courteous manner. 2. Promotes inclusiveness and collegiality by demonstrating respect and professionalism to others at all times 3. Models safe, ethical behavior, mitigating risk to the institution through sound business practices, and adherence to MD Anderson's Standards of Conduct, institutional policies and procedures 4. Meets time and attendance expectations and responds to requests in a timely manner, communicating expectations for procedures, service arrival, or project deliverables to coworkers 5. Admits when wrong, apologize and take steps to resolve a situation to help to coworkers before being asked. EDUCATION: Required: Bachelor's degree in Biomedical Engineering, Electrical Engineering, Physics, Applied Mathematics or related field. Preferred: PhD in Natural/Medical sciences or computational biology, ideally with postdoctoral experience EXPERIENCE: Required: Five years experience in scientific software development/analysis. With Master's degree, three years experience required. With PhD, one year of experience required. It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html Additional Information • Requisition ID: 149757 • Employment Status: Full-Time • Employee Status: Regular • Work Week: Day/Evening • Minimum Salary: US Dollar (USD) 81,000 • Midpoint Salary: US Dollar (USD) 101,500 • Maximum Salary : US Dollar (USD) 122,000 • FLSA: exempt and not eligible for overtime pay • Fund Type: Soft • Work Location: Hybrid Onsite/Remote • Pivotal Position: Yes • Science Jobs: Yes

Center Information: The Quantitative Biomedical Research Center (QBRC) is a well-established research center in the Department of Population and Data Sciences at the University of Texas Southwestern Medical Center (UTSW). It aims to foster collaborations involving quantitative methods and technologies in any aspect of biomedical research, particularly for understanding disease etiologies and... developing treatment and prevention strategies. We are actively recruiting new members to join this new and dynamic group. Position Title: Assistant Professor Duties & Responsibilities: We are seeking applicants for a faculty position in bioinformatics research in spatially resolved functional genomics. This project aims to adopt cutting-edge spatial molecular profiling techniques for innovative biomedical research. Specifically, we are seeking individuals with solid background in biology with strong interests in bioinformatics analysis. Related websites: QBRC: https://qbrc.swmed.edu/ At UTSW, there are great opportunities for researchers to collaborate with outstanding biomedical investigators and work on exciting research projects. UTSW provides a friendly, dynamic, collaborative, and integrative research and training environment with state-of-the-art facilities. UTSW offers an outstanding collaborative environment for research with world-class basic science and clinical colleagues, excellent benefits, and competitive salaries. Dallas is the ninth largest city by population and one of the most ethnically diverse in the US. As a major urban metroplex, the Dallas-Arlington-Fort Worth region continues to experience rapid population growth, with arts and culture offerings as renowned as the athletic franchises. Requirements: Applicants should hold a doctoral degree in Biomedical sciences, Computer Sciences, Statistics, Biostatistics, Engineering or related field. At least 1-2 years of training or work experience in the related fields. Preferred (but not required): working experience in AI, machine learning, predictive modeling, imaging analysis or digital pathology. Appointment rank will be commensurate with academic accomplishments and experience. Qualified candidates should apply online and upload a cover letter, curriculum vitae, and a written statement that describes your commitment to diversity, equity, and inclusion. UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. As an equal opportunity employer, UT Southwestern prohibits unlawful discrimination, including discrimination on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, gender expression, age, disability, genetic information, citizenship status, or veteran status. To learn more, please visit: https://jobs.utsouthwestern.edu/why-work-here/diversity-inclusion

The primary purpose of the Research Bioinformatician position is to carry out data preparation responsibilities related to cancer clinical trials, develop skilled statistical programs, perform statistical analysis associated with clinical data and prepare written reports to investigators. In addition, this position prepares statistical considerations for basic trial designs or grants and performs... biostatistical reviews of protocols. KEY FUNCTION: • Statistical Consulting and Collaboration: • Compiles, analyzes and reports statistical data for various projects including, but not limited to manual and computer-aided data abstraction and evaluation, clinical trials, computerized imaging and bioinformatics. • Prepares statistical considerations for basic trial designs and carries out uncomplicated statistical analyses independently, but completes statistical responsibilities for more complex projects with supervision. • Assists faculty in the development of new statistical methodology for measurement and analysis of data. • Applies advanced statistical methods, simulation models, and skilled statistical programming as needed. • Assesses relevant literature as well as existing data, evaluates the quality of data used in reports and assists with preparation and distribution of data for committee and scientific meetings. • Attends project meetings with collaborators with or without supervisor as directed by supervisor. • May present findings at relevant meetings both inside and outside of the institution as requested. • Protocol Review: • Participates in the protocol review process jointly with supervisor. • Statistical Reporting: • Prepares written reports to investigators jointly with supervisor. • May present findings at relevant meetings both inside and outside of the institution as requested. • Other duties as assigned. EDUCATION: Required: Master's degree in Biostatistics, Statistics, Bioinformatics, Mathematics or related field. Preferred: PhD in Biostatistics, Statistics, Bioinformatics, Mathematics or related field. EXPERIENCE: Required: Two years experience with mainframe and/or PC databases, document processing and statistical software such as SAS and S-Plus. With preferred degree, no required experience. It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html Additional Information • Requisition ID: 147658 • Employment Status: Full-Time • Employee Status: Regular • Work Week: Days • Minimum Salary: US Dollar (USD) 81,000 • Midpoint Salary: US Dollar (USD) 101,500 • Maximum Salary : US Dollar (USD) 122,000 • FLSA: exempt and not eligible for overtime pay • Fund Type: Soft • Work Location: Remote (within Texas only) • Pivotal Position: Yes • Science Jobs: Yes

Position Summary Caris Life Sciences is looking for a sharp, driven and goal oriented Bioinformatics Scientist Leader to provide bioinformatics and statistical analysis leadership and support for novel biomarker discovery derived from Caris’ proprietary ADAPT Biotargeting SystemTM. These high-profile roles will work closely with our R&D team and executive management to design experiments and... analyze complex clinical and translational data sets. We are looking for team oriented, hands on experts with a passion for personalized medicine and innovation in statistical and mathematical analyses. Job Responsibilities Develop and maintain statistical analytical tools and bioinformatics pipelines. Conduct analysis on biomarker discovery and clinical diagnostics data. Consult on experiment design and data interpretation for laboratory research. Contribute to design and development of informatics infrastructure. Adhere to coding and documentation standards and manage deliverables for area of responsibility. Required Qualifications PhD in bioinformatics, biostatistics, biomedical engineering, computer science and other related disciplines. Demonstrated track record of success. Solid understanding of principles and analytical methodologies in computational biology and bioinformatics. Hands-on experience of state-of-the-art bioinformatics tools, including NGS and proteomic piplines. Proven ability for developing and maintaining bioinformatics pipelines. Experience in developing database and data-driven applications. Programming skills with Perl, Python, shell scripting and/or Java. Skills in statistical analysis and proficiency with statistical package such as R and SAS. Ability to understand laboratory and clinical data. Conditions of Employment: Individuals must successfully complete pre-employment process, which includes criminal background check, drug screening, and reference verification. Also, individual must be fully vaccinated for COVID-19 by the date of hire to be considered for U.S.-based jobs, if not currently employed by Caris Life Sciences. Preferred Qualifications Familiarity with clinical trial design and clinical data analysis is highly desirable. Proficient verbal and written communication skills. Willingness to share and receive information and ideas from all levels of the organization in order to achieve the desired results. Training All job specific, safety, and compliance training are assigned based on the job functions associated with this employee. This job description reflects management’s assignment of essential functions. Nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time. Caris Life Sciences is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, gender, gender identity, sexual orientation, age, status as a protected veteran, among other things, or status as a qualified individual with disability

The Department of Biophysics and the Lyda Hill Department of Bioinformatics (Green Center for Systems Biology) at The University of Texas Southwestern Medical Center invite applications for a jointly appointed tenure-track faculty position, primarily at the level of assistant professor, but other ranks may be considered. Appointment rank will be commensurate with academic accomplishments and... experience. We seek outstanding candidates who work at the interface of super-resolution light microscopy and cryoelectron tomography (cryoET). We are interested in both developers of these cutting-edge technologies and high-end users focused on important, mechanistic questions in biophysics and/or cell biology. Ideal candidates will have experience in both super-resolution light microscopy and cryoelectron microscopy. Successful candidates will benefit from an infrastructure highly conducive to the creation of new methods and approaches. In cryoET, they will have access to a newly purchased Thermo Fisher Aquilos II cryoFIB/SEM equipped with both internal cryo-widefield and external Leica cryo-confocal fluorescence microscopes, as well as two Titan Krios cryoelectron microscopes with direct electron detectors, including one with the latest generation cold field emission gun and Selectris-X energy filter. In light microscopy they will be embedded in a program with an outstanding track record of engineering super-resolution, light-sheet and cleared tissue microscopes that are flexibly designed to address a variety of imaging questions. To this effect the Green Center for Systems Biology houses ~25 isolated microscope development bays equipped with optical tables. The Department of Bioinformatics is responsible for running BioHPC, a high performance computing and storage facility which is equipped with ~1000 CPU and ~120 GPU nodes connected to 50 PB of storage for on premise data analysis. All instruments have direct mounts to this computing infrastructure. Besides offering a home in two vibrant, interactive, and physically neighboring Departments, UTSW has a highly collaborative and inclusive environment encompassing the entire spectrum of basic, translational, and clinical research. Candidates must have a PhD degree in biomedical imaging or a related discipline and relevant work experience. The search committee is particularly interested in candidates who, through their research, teaching, and/or service, will contribute to the diversity and excellence of the academic community. Applicants should submit a curriculum vitae, a concise description of previous research accomplishments and future plans (3 page limit) to https://jobs.utsouthwestern.edu/. Please arrange for referees to send reference letters to BiophysicsSearch@utsouthwestern.edu. The screening of applications will begin December 1, 2021 and continue on a rolling basis until the position is filled. Questions may be emailed to BiophysicsSearch@UTSouthwestern.edu. UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. As an equal opportunity employer, UT Southwestern prohibits unlawful discrimination, including discrimination on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, gender expression, age, disability, genetic information, citizenship status, or veteran status. To learn more, please visit: https://jobs.utsouthwestern.edu/why-work-here/diversity-inclusion

Job Summary The Bioinformatics department has an opening for a Data Scientist I. This role will employ a highly skilled data scientist with expertise in developing machine learning models to curate and analyze large, multi-modal datasets generated by the SimCenter at UT Southwestern Medical School. Experience with using machine learning for analyses of video-based data sets is a plus. They will... work closely with our software and AI engineers to ensure that the models are integrated into actionable user interfaces. Job Duties • Analyzes and develops formalisms, algorithms and software for applications in biomedical research. • Develops and maintains software tools and infrastructure for resolving specific problems. • Assists in the development, testing and revision of programs in a team with diverse bioinformatics expertise. • Performs other duties as assigned. Responsibilities: • Clean, organize, and analyze large, multi-model data sets • Build, train, test, and evaluate machine learning models on our proprietary data sets • Understand and implement the latest video-based machine learning models • Continuously improve the performance of the models by analyzing results and experimenting with different techniques • Collaboratively ensure the models are integrated into the user interfaces. Experience and Education M.S. in Computer Science, Bioinformatics, (Bio)mathematics, (Bio)statistics, Physics, Electrical Engineering, or related field OR B.S. with demonstrated experience in broadly defined areas of bioinformatics. 0 - 2 years post-graduation experience in data analysis and/or scientific software development. Technical Skills/Specifications: • Strong experience with Python and related data science libraries such as Pandas, Numpy, Scikit-learn. • Strong experience with machine learning frameworks such as Tensorflow or PyTorch. • Experience with video analysis with machine learning, specifically with CNNs and other deep learning models. • Experience with data visualization tools such as Matplotlib or Seaborn. • Strong understanding of data science and machine learning principles and best practices. • Experience with cloud platforms such as AWS or GCP. • Strong debugging and problem-solving skills. Why UT Southwestern? With over 75 years of excellence in Dallas-Fort Worth, Texas, UT Southwestern is committed to excellence, innovation, teamwork, and compassion. At UT Southwestern, we invest in you with opportunities for career growth and development that align with your future goals and help to provide security for you and your family. Our highly competitive benefits package offers healthcare, PTO and paid holidays, on-site childcare, wage, merit increases and so much more that are all available on the day you start work. UT Southwestern is honored to be a Veteran Friendly work environment that is home to approximately 800 veterans. We value your integrity, dedication, and the commitment you’ve made to our country. We’re proud to support your next mission. Ranked by Forbes as one of the Top 10 National Employers, we invite you to be a part of the UT Southwestern team where you’ll discover teamwork, professionalism, and consistent opportunities for growth. This position is security-sensitive and subject to Texas Education Code §51.215, which authorizes UT Southwestern to obtain criminal history record information. UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. As an equal opportunity employer, UT Southwestern prohibits unlawful discrimination, including discrimination on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, gender expression, age, disability, genetic information, citizenship status, or veteran status. To learn more, please visit: https://jobs.utsouthwestern.edu/why-work-here/diversity-inclusion

Invitae (NYSE: NVTA) is a leading medical genetics company trusted by millions of patients and their providers to deliver timely genetic information using digital technology. We aim to provide accurate and actionable answers to strengthen medical decision-making for individuals and their families. Invitae's genetics experts apply a rigorous approach to data and research, serving as the foundation... of their mission to bring comprehensive genetic information into mainstream medicine to improve healthcare for billions of people. Manager, Bioinformatics Operations Remote in the USA. Invitae is dedicated to bringing comprehensive genetic information into mainstream medicine to improve healthcare for billions of people. Our team is driven to make a difference for the patients we serve. We are leading the transformation of the genetics industry by making clinical-grade genetic information affordable and accessible to guide health decisions across all stages of life. We’re looking for people who are passionate about helping improve healthcare to join us. We are seeking a Clinical Data Quality Analyst Lead who will support the team in monitoring our genetic testing pipeline using custom software tools to ensure samples move through efficiently. Successful candidates will take initiative to coordinate and coach their team, set a clear direction aligned with department and company objectives, and innovate new approaches to existing workflows. An important part of this job is to be able to clearly communicate technical findings to non-technical teammates. What You’ll Be Doing • Recruit, hire, align, and coach a high-performing team • Serve the team as both a technical and people leader • Translate business requirements across the company to best-in-class experiences • Facilitate problem-solving across teams and implement data-driven decisions • Anticipate and respond to quickly changing priorities • Proactively recognize production bottlenecks, investigate their causes, and facilitate lasting solutions • Drive technical excellence and effective execution within the team • Develop and improve SOPs • Assist process development programs What You Bring • Flexible schedule, including being able to commit to weekend support if required • 4+ years experience in NGS bioinformatics (eg. samtools, bwa, Picard, GATK) or combination of education and experience • 2+ years experience working in a molecular biology context and troubleshooting lab or software pipelines and a BS Degree, or 4 years total related experience. • 2+ yrs experience manipulating data and troubleshooting applications in UNIX-based environments • Successfully built and led teams in a production or manufacturing environment • Evaluated and established strategic goals in an production environment • Coached and mentored team members of diverse backgrounds and skillsets • Exemplary communication and interpersonal skills with people of various backgrounds • Successfully triage and resolve production incidents • Familiarity with LIMS best practices and working in a lab environment • Working knowledge of molecular genetics and experience with next generation sequencing data, preferably in a production setting • Experience writing scripts to analyze data (e.g. Python, R) • Superior oral and written communication skills and the ability to clearly communicate technical findings to non-technical teammates • Excellent ability to work with people across different teams and specializations • Preferred: Hands-on molecular biology wet lab experience • Preferred: Background in life and physical sciences • Preferred: Software development and database querying experience (e.g. Flask with PostgreSQL) By joining Invitae, you’ll work alongside some of the world’s experts in genetics and healthcare at the forefront of genetic medicine. We’ve crafted a culture that empowers our teams and our teammates to have the biggest impact and to explore their interests and capabilities. We prize freedom with accountability and offer significant flexibility, along with excellent benefits and competitive pay in a fast-growing organization. Join us! Please apply even if you don’t meet all of the “What you bring” requirements noted. It’s rare that someone checks every single item, it’s ok, we encourage you to apply anyway. At Invitae, we value diversity and provide equal employment opportunities (EEO) to all employees and applicants without regard to race, color, religion, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. We will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of the San Francisco Fair Chance Ordinance. This salary range is an estimate, and the actual salary may vary based on a wide range of factors, including your skills, qualifications, experience and location. This position is eligible for benefits including but not limited to medical, dental, vision, life insurance, disability coverage, flexible paid time off, Spring Health, Carrot Fertility, participation in a 401k with company match, ESPP, and many other additional voluntary benefits. Invitae also offers generous paid leave programs so you can spend time with your new child, recover from your own illness or care for a sick family member. USA National Pay Range $134,720—$168,400 USD Please apply even if you don’t meet all of the “What you bring” requirements noted. It’s rare that someone checks every single item, it’s ok, we encourage you to apply anyways. Join us! At Invitae, we value diversity and provide equal employment opportunities (EEO) to all employees and applicants without regard to race, color, religion, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. We will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of the San Francisco Fair Chance Ordinance. We truly believe a diverse workplace is crucial to our company's success and to better serve our diverse patients. Your input is especially valuable. We’d greatly appreciate it if you can take a quick moment to make your selection(s) below. Submissions will be anonymous. You can find a detailed explanation of our privacy practices here

Description Job Description... The CDC’s Advanced Molecular Detection (AMD) program is modernizing the public health system’s disease-investigation capabilities by employing the latest technologies and improving capacity in laboratory science, bioinformatics, and epidemiology throughout the nation. CDC’s Office of Advanced Molecular Detection (OAMD) works with experts across CDC to ensure the United States has the infrastructure, including technology, needed to protect Americans from infectious disease threats. OAMD collaborates with other CDC programs to facilitate development and piloting of next-generation diagnostics and protocols. These tools are then leveraged by programs across CDC to be brought to scale in state and local public health laboratories nationwide. The program is amid migrating public health scientific computing infrastructure partially to the cloud to be able to take advantage of scalable resources. As part of this important effort, you will contribute to the understanding of the existing computing infrastructure and policies so they can be adapted to the cloud. You will be primarily responsible for assessment and verification of documentation of the on-premise infrastructure. You will work closely with and learn from a team of experienced System Administrators and will have the opportunity to interact with CDC scientists and other IT personnel to verify reference material and bring documentation and practice into alignment. The position will offer the valuable experience of working in High Performance Cluster computing environment in support of public health scientific efforts at the CDC. Qualifications: • A solid understanding of Linux and moderately good understanding of Windows. • A self-starter who seeks out answers from appropriate stakeholders as needed to verify and correct existing documentation. Eligibility: Applicants should have a keen interest in careers in public health and in developing strong public health analytic and evaluation skills. Applicants must: • Be a US citizen or permanent resident; • Hold a bachelor's degree from an accredited academic institution; • Currently pursuing a Master's in Computer Science/related degree; • Submit an official transcript; • Submit two letters of recommendation; • Pass a background check for CDC clearance; • Be willing to relocate to Atlanta, GA at own expense. Pay Range: Pay Range $44,200.00 - $68,000.00 - $91,800.00 The Leidos pay range for this job level is a general guideline only and not a guarantee of compensation or salary. Additional factors considered in extending an offer include (but are not limited to) responsibilities of the job, education, experience, knowledge, skills, and abilities, as well as internal equity, alignment with market data, applicable bargaining agreement (if any), or other law

About City of Hope City of Hope is an independent biomedical research and treatment organization for cancer, diabetes and other life-threatening diseases... Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope's translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution. AccessHope™, a subsidiary launched in 2019 serves employers and their health care partners by providing access to City of Hope's specialized cancer expertise. A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation's "Best Hospitals" in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona. City of Hope's commitment to Diversity, Equity and Inclusion We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work -- and that our teams align with the people we serve in order to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people. Position Summary We are seeking a talented and motivated Postdoctoral Fellow within the multidisciplinary research team headed by Dr. Ajay Goel, Professor and Chair, Department of Molecular Diagnostics and Experimental Therapeutics and Associate Director of Basic Sciences, City of Hope Comprehensive Cancer. Our research group comprises of basic biologists, gastroenterologists, surgeons, medical oncologists and bioinformaticians, undertaking a number of collaborative projects involving large international consortia. Our research is focused on translational research as it relates to genomic and epigenomic characterization of various gastrointestinal cancers (GI) including colorectal, pancreatic and gastric cancers, and some of the key research topics include: 1) Development of circulating DNA/RNA-based liquid biopsy biomarkers for cancer diagnosis, prognosis and predictive response to various therapies. 2) Study the epigenetic basis of GI cancers (e.g. aberrant DNA methylation, histone modifications and non-coding RNAs. 3) The genetic basis of early-onset and familial/hereditary colorectal cancers. 4) The role of tumor microenvironment, stem cells, immune regulation and identification of novel targeted therapies. 5) The role of extracellular vesicles/exosomes as in cancer pathogenesis and their role as disease biomarkers. Our group performs cutting-edge research in GI oncology, is very productive and publishes in high-impact journals such as Gastroenterology, Cancer Cell, PNAS, JNCI, Clinical Cancer Research, Nature Communications, Nature Reviews Gastroenterology and Hepatology, Annals of Surgery etc. Key Responsibilities include: • Exploration of cell-free DNA-based, liquid biopsy biomarkers for the early-detection of gastrointestinal cancers (including colorectal, pancreatic, gastric, liver and esophageal). • Establish innovative methodologies involving non-coding RNAs-based biomarkers for the earlier diagnosis, prognosis and predictive responses to chemotherapy in gastrointestinal neoplasia. • Understanding the genetic basis of early-onset and familial/hereditary colorectal cancers • Molecular mechanisms of cancer pathogenesis, the role of stem cells in the context of chemo resistance chemo-sensitization in cancer cells • Gut microbiome and its influence in gastrointestinal cancers The position is largely computational and biostatistical but involves substantial collaboration with wet-lab researchers providing data and is focused on fundamental biology. This interdisciplinary position offers opportunities to address important questions in computational biology and cancer genomics with first access to large novel data sets from various genomic/epigenomic platforms. We have a strong preference for bioinformaticians/biostatistician/computational biologists with a deep appreciation of biological phenomena or, alternatively, experimentalists with a solid background in bioinformatics/computational biology analysis of transcriptomic and genomic data with regard to detection of differentially expressed genes, noncoding RNAs, DNA methylation and differential processing profiles. Basic education, experience and skills required for consideration: • PhD in bioinformatics, computer science, data science, mathematics, statistics, physics or equivalent • Hands-on and documented experience in analyzing RNA-Seq data, small RNA-Seq data, Methylation sequencing, WES, 16S RNA seq etc. • Ability to do multi-omic analysis using a combination of various sequencing datasets Additional Information: • For more information about the groundbreaking research taking place in the Ajay Goel, Ph.D lab, please visit www.cityofhope.org/mdet . • The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate's experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time. • As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates. City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability. #LI-MA #PD