Bioinformatics Jobs

Description Are you passionate about identifying, defining, and solving some of the nation's hardest problems? Do you enjoy being a part of diverse, interdisciplinary teams? If so, we are looking for someone like you to join our team at APL! The Applied Biological Sciences Group (QLA), located within the Asymmetric Operations Sector (AOS), is committed to APL's mission to provide critical contributions to critical challenges. We seek a highly motivated scientist with expertise in bioinformatics and computational biology to develop technical solutions to address the challenges facing our nation. Candidates should be curious, collaborative, and dedicated to leveraging world class expertise to develop real-world solutions for national security and health application spaces as part of a dynamic and innovative interdisciplinary team. APL works across the US Government applying the full spectrum of science and engineering to improve the nation’s ability to safely mitigate biological threats. We partner closely across the whole of the Johns Hopkins enterprise, and with collaborators in government, academia, and industry, to develop innovative science and technology solutions to biosecurity challenges. We strive to ensure the health of individuals and the nation through applied research, which drives development and implementation of ground-breaking capabilities in sensing and detection, threat characterization, modeling and simulation, and more. As a bioinformatics and computational biology professional, you will… • Lead and support bioinformatics and data science aspects of genomics and systems biology projects • Use open-source tools and custom pipelines on a High-Performance Computing (HPC) Cluster • Be able to operate in a Linux environment, using at a minimum BASH, Python, and R languages • Perform sequence analysis on Illumina, PacBio, and Oxford Nanopore data • Support internal Laboratory Information Management System (LIMS) for sample tracking through analysis pipelines • Identify and implement analysis tools for multi-omic analysis • Develop novel bioinformatics and computational biology approaches and tools Qualifications You meet our minimum qualifications for the job if you have... • A Master's degree in Bioinformatics, Computer Science, Applied Mathematics, or a combination of equivalent level experience/education • The ability to model and simulate biological systems in silico using mathematical concepts such as matrices, differential equations, and standard modeling concepts • Familiarity with algorithms in computer science and applied mathematics commonly used for analyzing biological data, such as Expectation-Maximization, Dynamic Programming, K-Nearest-Neighbors (KNN), Support Vector Machines (SVMs), and other Artificial Intelligence (AI) and Machine Learning (ML) approaches to data analysis and decision support • The ability to troubleshoot algorithms and implement software programs for the analysis of complex data sets • Experience with cluster computing environment and/or resource schedulers for high throughput (parallel) computations, and heuristics for dealing with large data sets; The ability to scale analyses from low computational loads to high, and vice versa • Familiarity with open-source software and published literature related to new tools and an ability to examine the capabilities and limitations of such tools for sponsor related requirements • Experience with BASH, Python, R and Linux environments • Are able to obtain a Secret level clearance. If selected, you will be subject to a government security clearance investigation and must meet the requirements for access to classified information. Eligibility requirements include U.S. citizenship You'll go above and beyond our minimum requirements if you have... • A PhD degree in Bioinformatics, Computer Science, Applied Mathematics, or related field • Experience developing and leading large bioinformatics and computational biology efforts • Experience performing (or familiarity with) laboratory sequencing preparations and workflows • Experience with molecular and laboratory techniques • Experience leading multidisciplinary teams and projects • Outstanding interpersonal skills and the ability to clearly communicate complex topics • Experience working in Unclassified and Classified areas • A publication record in computational biology and/or bioinformatics analysis Why work at APL? The Johns Hopkins University Applied Physics Laboratory (APL) brings world-class expertise to our nation’s most critical defense, security, space and science challenges. While we are dedicated to solving complex challenges and pioneering new technologies, what makes us truly outstanding is our culture. We offer a vibrant, welcoming atmosphere where you can bring your authentic self to work, continue to grow, and build strong connections with inspiring teammates. At APL, we celebrate our differences and encourage creativity and bold, new ideas. Our employees enjoy generous benefits, including a robust education assistance program, unparalleled retirement contributions, and a healthy work/life balance. APL’s campus is located in the Baltimore-Washington metro area. Learn more about our career opportunities at http://www.jhuapl.edu/careers. About Us APL is an Equal Opportunity/Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to race, creed, color, religion, sex, gender identity or expression, sexual orientation, national origin, age, physical or mental disability, genetic information, veteran status, occupation, marital or familial status, political opinion, personal appearance, or any other characteristic protected by applicable law. APL is committed to promoting an innovative environment that embraces diversity, encourages creativity, and supports inclusion of new ideas. In doing so, we are committed to providing reasonable accommodation to individuals of all abilities, including those with disabilities. If you require a reasonable accommodation to participate in any part of the hiring process, please contact Accommodations@jhuapl.edu. Only by ensuring that everyone’s voice is heard are we empowered to be bold, do great things, and make the world a better place. The referenced pay range is based on JHU APL’s good faith belief at the time of posting. Actual compensation may vary based on factors such as geographic location, work experience, market conditions, education/training and skill level with consideration for internal parity. For salaried employees scheduled to work less than 40 hours per week, annual salary will be prorated based on the number of hours worked. APL may offer bonuses or other forms of compensation per internal policy and/or contractual designation. Additional compensation may be provided in the form of a sign-on bonus, relocation benefits, locality allowance or discretionary payments for exceptional performance. APL provides eligible staff with a comprehensive benefits package including retirement plans, paid time off, medical, dental, vision, life insurance, short-term disability, long-term disability, flexible spending accounts, education assistance, and training and development. Applications are accepted on a rolling basis. Minimum Rate $90,000 Annually Maximum Rate $230,000 Annually

At Quest, we are on a continuous journey of discovery and development. It’s this attitude that has made us an industry leader and the #1 Diagnostic Lab in the US. For those joining us, we offer exciting and fast-moving career opportunities where you can affect change at a rate unheard of in many organizations of our size and scope. While we invest in and develop technology to drive our innovations, our ongoing success relies on our people. Quest Diagnostics Specialty Genetics products provide specific answers that clinicians need to deliver the appropriate diagnostic and prognostic care to their patients. You will work for the world leader in the industry, with a career where you will have the opportunity to collaborate and affect change while expanding your leadership skills and technical knowledge. You can make a real impact in a market that is growing and developing. This position is in our Bioinformatics Solutions Engineering group, part of the Research and Development organization, in Molecular Genomics & Oncology unit. The team supports genetic/genomic testing in a highly regulated CAP/CLIA laboratory environment primarily using short and long-read sequencing as the basis of evidence. The right candidate will know how to balance innovation, standards, and quality with a practical understanding of when each is appropriate. The Bioinformatics Solutions Engineering group is a cross-functional unit focusing on end-to-end design, develop, document, validation and launching of new high quality diagnostic tests and services for the benefit our patients. This professional can work in a 100% remote capacity and must be located in the US. • Lead technical design, implementation and delivery of projects aiming to launch new diagnostic tests and services. Act as technical owner for your project, being responsible for the end-to-end solution from technical side. • Work with cross-functional partners from business, operations, IT, R&D lab, geneticists, medical directors, and other bioinformatics stakeholders to create solutions that meet business and operational requirements. • Lead solution architecture and interface design including system architecture for bioinformatics and detailed data flow mapping. • Collaborate with stakeholders to ensure compliance of the solution with internal and external IT security and clinical policies and processes. • Work with bioinformatics domain leaders to select appropriate technology platforms for each step in the diagnostic process. • Oversee end-to-end testing and diagnostic test validation activities with the project team. • Lead the technical documentation and plan and execute handover to operations to ensure effective launch and operation of the solution. • Work with project management and report on progress, analyze risks and escalate issues to ensure accurate project management. Required Work Experience: • BS with 7+ years of experience, MS with 4+ years of experience, or PhD with 3+ years of experience in an industrial or academic setting working with clinical and biological data or equivalent and underlying technologies including bioinformatic methods, database development, query/scripting/programming languages, cloud development, agile methodology, DevOps and other data analysis tools. • At least 5 years of experience working in a regulated industrial life sciences environment. • At least 4 years of professional software development or technical engineering experience Preferred Work Experience / Skills: • Thorough understanding of end-to-end diagnostic process including ordering, wet lab, dry lab, result interpretation and result and data delivery. • Experience with solution design, system architecture, solution architecture, data flow modeling. • Experience in leading technical design and implementation of complex projects. • Experience with sequencing data analysis, bioinformatics, variant data analysis. • Knowledge of bioinformatics tools and workflow managers for sequencing data analysis and quality control. • Experience working with SQL and NoSQL databases. • Experience with designing and working with application programming interfaces (e.g. JSON based RESTful APIs). • Experience with designing and implementing solutions in the cloud. AWS experience is preferred. • Experience of working in clinical diagnostics setting (regulations, controlled processes, diagnostic test validation, environment management). • Solid understanding of human genetics and oncology in diagnostic setting. • Solid understanding of web lab process for DNA sequencing and working with or developing LIMS systems. • Infrastructure management: Terraform, AWS CDK. • Architecture design: Microsoft Visio, DrawIO, similar for crafting architecture diagrams. • Programming Languages: Python, javascript/typescript, R, etc. • Containerizing: Docker • Web Frameworks: Python Flask, React Native, Bootstrap • Reporting: R Markdown, Jupyter Notebook • Visualization: Experience with any of ggplot2/tidyverse, Plotly, matplot lib, Tableau, d3.js • Source Control: Git • CI/CD: Gitlab CI/CD, Github CI/CD Education: Bachelor’s Degree Required Master’s Degree or PhD Preferred Equal Opportunity Employer: Race/Color/Sex/Sexual Orientation/Gender Identity/Religion/National Origin/Disability/Vets

Assistant Professor Tenure Track Immunogenetics and Bioinformatics at Childrens Hospital of Philadelphia (CHOP) Perelman School of Medicine - Pathology and Laboratory Medicine Location: Philadelphia, PA Open Date: Sep 28, 2021 Deadline: Sep 28, 2023 at 11:59 PM Eastern Time Children's Hospital of Philadelphia and the Department of Pathology and Laboratory Medicine at the Perelman School of Medicine at the University of Pennsylvania seek candidates for an Assistant Professor position in the tenure track. Expertise is required in the specific area of Immunogenetics and Bioinformatics, with demonstrated excellence in research, clinical service, and teaching. The successful applicant will develop and harness computational and big data approaches to drive biological discoveries and medical innovations. Computational biologists who incorporate wet lab research programs are welcome to apply. Applicants must be American College of Histocompatibility & Immunogenetics certified, or board eligible. Applicants must have an M.D. or equivalent degree. Teaching responsibilities may include establishing and maintaining an independent, extramurally funded research program, and teaching and mentoring graduate and medical students. Clinical responsibilities may include serving as Assistant Director for, and signing out cases in, the Clinical Immunogenetics Laboratory of the Children's Hospital of Philadelphia. Research or scholarship responsibilities may include advanced image analyses, machine learning approaches to laboratory data, and integration of disparate data sets into supervised learning models.". The position is affiliated with the newly founded Center for Computational and Genomic Medicine (CCGM) at the Children's Hospital of Philadelphia. CCGM is housed in the state-of-the-art Colket Translational Research Building. A generous recruitment package and lab space will be provided, together with excellent institutional and core research resources. The recruitment is part of a campus-wide initiative to promote innovative computational strategies for advancing human health and therapy development. We seek candidates who embrace and reflect diversity in the broadest sense. The University of Pennsylvania and Children's Hospital of Philadelphia are EOEs. Minorities/women/individuals with disabilities/protected veterans are encouraged to apply. To apply, visit https://apply.interfolio.com/94529 The University of Pennsylvania values diversity and seeks talented students, faculty and staff from diverse backgrounds. The University of Pennsylvania is an equal opportunity and affirmative action employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status or any other legally protected class. Questions or concerns about this should be directed to the Executive Director of the Office of Affirmative Action and Equal Opportunity Programs, University of Pennsylvania, 421 Franklin Building, 3451 Walnut Street, Philadelphia, PA 19104-6205; or (215) 898-6993 (Voice) or (215) 898-7803 (TDD). Copyright ©2021 Jobelephant.com Inc. All rights reserved. Posted by the FREE value-added recruitment advertising agency jeid-17f25d524152d542be0423e3549066e2

RISE Bioinformatics Engineer https://www.icds.psu.edu/ at Penn State is seeking a Bioinformatician or Computational Biologist for their https://www.icds.psu.edu/computing-services/rise/ Engagement team. You will be an integral contributor to a fast-paced and growing team of specialists supported by an exciting, ongoing $125 million Penn State investment in ICDS cyber-ecosystem, called “Roar”. With ICDS, our RISE team members have the unique opportunity to support and participate in groundbreaking academic research at Penn State. This position will primarily focus on supporting a new interdisciplinary center, which sits at the intersection of Data Sciences and Molecular and Cellular Sciences. The center will serve as a leader in integrating various publicly accessible data sets, which diverse teams of scientists will synthesize to answer cutting-edge questions. Work Arrangement: This position has the potential to be a hybrid of remote and on-site work, with a minimum of 3 days per week on-site. This position may not be supportive of fully remote work. This is a limited-term position funded for 3 years from the start date, with excellent chances of renewal. As a RISE Bioinformatician or Computational Biologist, you would have the following responsibilities: • Provide advanced engineering and support in the design and development of bioinformatics science gateways and pipelines, with a particular emphasis on analysis of mass spectrometry, genomics, transcriptomics, proteomics, and metabolomics datasets. • Formulate and define the scope, objectives, and detailed specifications for bioinformatics projects. Collaborate with researchers to understand their data requirements and design custom solutions. • Offer guidance and support on the selection and application of bioinformatics and computational biology tools and pipelines, especially those related to sequence alignment, gene expression analysis, and variant calling, following open and reproducible science best practices. Develop and maintain quality assurance protocols for workflows to guarantee the reliability and reproducibility of results. • Stay up-to-date with the latest advancements in bioinformatics, computational biology, and available biological datasets. • Work with the center project manager, scientific working groups, and graduate students to deliver work products on time and to predefined specifications. • Provide technical expertise in the wrangling, harmonizing, and standardizing of existing biological datasets, including advanced experience with mass spectrometry data and/or next-generation sequencing data. Implement comprehensive quality control measures to ensure data accuracy and consistency. • Project manage graduate students who will work with you to support data science efforts. Education and Experience: This position will be filled at an Intermediate or Advanced Professional level, depending on the successful candidate's experience and education or an equivalent combination. • Minimum education and experience are a Bachelor's degree in Computational Biology or Bioinformatics, and 1 years of experience, or an equivalent combination of education and experience. • Candidates with a PhD in Bioinformatics, Computational Biology, or a related discipline and 3 years of experience, or an equivalent combination of education and experience are strongly preferred. Skills and Abilities: • Advanced expertise in Python and/or R for complex data analysis, scripting, and statistical modeling, with a particular focus on sequence alignment algorithms, structural prediction, gene expression analysis, and variant calling. Additional proficiency in languages like Perl or C is beneficial for systems-level bioinformatics applications. • Mastery in using bioinformatics or computational biology software (like BLAST, GATK, Bioconductor) • Experience in working with large-scale biological databases using SQL or NoSQL, with strong skills in big data analytics, ETL processes, and the ability to extract meaningful insights from complex datasets. • Understanding of genetic principles, molecular biology techniques, and genomic databases. • Familiarity with next-generation sequencing (NGS) data, its analysis, interpretation, and integration with mass spectrometry and other omics data. • Practical experience with any of the following datasets: XL-MS (PRIDE), AlphaFold (EBI), M.S.A., DMS (MAVE), P.P.I. (STRINGS), Metabolic networks (KEGG), Expression (GEO, SRA), Seq-methods (e.g., Hi-C, CRISPRi, etc.) In addition, our desired qualifications and skills include but are not limited to the following: • Proven track record of publications in peer-reviewed journals and/or conference proceedings, demonstrating significant contributions to the field. • Expertise in machine learning algorithms for pattern recognition and predictive modeling in biological data. • Experience developing new bioinformatics tools as dictated by research needs. • Experience with high-performance computing (HPC) environments, parallel computing, and cloud-based computational resources. • Experience with software containerization, workflow management systems, and adherence to open and reproducible science practices. • Proficiency in creating sophisticated data visualizations to represent complex biological data and trends. Candidates must also have impeccable ethics and integrity with a strong work ethic, strong interpersonal and written skills, and the ability to work well in a team environment. Candidates are required to provide the following: • A current Curriculum Vitae (CV) or Resume • A cover letter expressing detailing the candidate's interest in the role http://psu.edu/ is committed to and accountable for advancing diversity, equity, and inclusion in all its forms. We embrace individual uniqueness, foster a culture of inclusive excellence that supports both broad and specific diversity initiatives, leverage the educational and institutional benefits of diversity, and engage all individuals to help them thrive. We value inclusive excellence as a core strength and an essential element of our public service mission. Penn State offers a generous benefits package that includes health insurance, dental and vision plans, retirement plans, a 75% tuition discount for full-time employees, their spouse, and children to attend any Penn State campus, and paid vacation and sick days. More information about benefits is available here: https://hr.psu.edu/benefits Apply online at https://apptrkr.com/5800085 CAMPUS SECURITY CRIME STATISTICS: For more about safety at Penn State, and to review the Annual Security Report which contains information about crime statistics and other safety and security matters, please go to http://www.police.psu.edu/clery/, which will also provide you with detail on how to request a hard copy of the Annual Security Report. Penn State is an equal opportunity, affirmative action employer, and is committed to providing employment opportunities to all qualified applicants without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability or protected veteran status. Copyright ©2024 Jobelephant.com Inc. All rights reserved. https://www.jobelephant.com/

Look for more than answers. As a Bioinformatics Engineer, you will work for the world leader in the industry, with a career where you will have the opportunity to collaborate and affect change while expanding your leadership skills and technical knowledge. You can make a real impact in a market that is growing and developing. This position is in our Bioinformatics Solutions Engineering group, part of the Research and Development organization, in Molecular Genomics & Oncology unit. The team supports genetic/genomic testing in a highly regulated CAP/CLIA laboratory environment primarily using short and long-read sequencing as the basis of evidence. The right candidate will know how to balance innovation, standards, and quality with a practical understanding of when each is appropriate. The Bioinformatics Solutions Engineering group is a cross-functional unit focusing on end-to-end design, develop, document, validation and launching of new high quality diagnostic tests and services for the benefit our patients. This person can work 100% remote and must be located in the US. • Develop, validate, and implement new software applications, databases, processes, and interfaces relating to next-generation sequencing (NGS) data analysis, advanced diagnostic testing development and validation, data quality review, and clinical reporting. • Serve as SME on specific systems/workflows supporting advanced development and high-tier production support. • Participate in resolution of support requests. Regularly report progress and prepare data analyses for internal review • Prepare reports and other communications of technical activities related to business objectives such as product/process development and improvement. • Activities may be focused individual projects or, more usually, assignments as a member of a project team, often working closely with other Software Developers, R&D bench scientists, Genetic Counselors, Operations Scientists, and other technical business partners. 3+ years of experience with a Bachelor's degree or 1+ year with a Master's degree and experience in an industrial or academic setting working with clinical and biological data or equivalent and underlying technologies including bioinformatic methods, database development, query/scripting/programming languages, cloud development, agile methodology, DevOps and other data analysis tools. Preferred Work Experience / Skills: • Bioinformatics tools such as Dragen, bwa, VEP, FastQC, MultiQC, samtools, bedtools • Experience with sequencing data analysis, bioinformatics, variant data analysis • Pipeline workflow management languages: Nextflow (preferred), Cromwell, CWL, etc. • Database: SQL (e.g., postgress, MySQL), understanding of NoSQL databases • Cloud Computing: AWS • Infrastructure management: Terraform, AWS CDK • Programming Languages: Advanced level with interpreted/scripting languages such as Python, javascript/typescript, R, etc. • Containerizing: Docker • Experience with designing and working with application programming interfaces (e.g. JSON based RESTful APIs) • Web Frameworks: Python Flask, React Native, Bootstrap • Reporting: Familiarity with R Markdown, Jupyter Notebook • Visualization: Experience with any of ggplot2/tidyverse, Plotly, matplot lib, Tableau, d3.js • Source Control: Git • CI/CD: Gitlab CI/CD, Github CI/CD • Understanding of environment management • Experience of working in clinical diagnostics setting (regulations, controlled processes, environment management) is a plus. Education: Bachelor’s Degree(Required) Master’s Degree Equal Opportunity Employer: Race/Color/Sex/Sexual Orientation/Gender Identity/Religion/National Origin/Disability/Vets

Organization Overview Our Vertebrate Genome Laboratory conducts research and services for individual and large vertebrate genome projects such as the Vertebrate Genomes Project (VGP/G10K) that aims to sequence high-quality genomes for all 66,000 vertebrate species on the planet. https://vertebrategenomesproject.org/. Overview We seek a highly motivated individual with a strong background in Computer Science and Genomics to join the Bioinformatics team of the Vertebrate Genome Laboratory (www.vertebrategenomelab.org) at the Rockefeller University. This person will generate reference genomes of eukaryotic species as part of the Vertebrate Genomes Project (VGP, www.vertebrategenomesproject.org) and the Earth Biogenome Project (EBP, https://www.earthbiogenome.org/). In particular, the individual is expected to help achieve the following goals: • Work closely with the VGL data production and bioinformatics teams, and the broader international scientific community of the VGP, to actively generate draft high-quality genomes. • Help make the current pipeline, which is already heavily streamlined, fully automated, such that the sequencing data is automatically processed into draft assemblies along with QC, ready for manual curation. • Consistently improve the pipeline for genome assembly quality and efficiency, based on feedback from genome curators, incorporating novel data types, and adding or help in designing novel tools. Our current workflow involves: 1) in-house generation of a variety of long- (PacBio, Nanopore) and short- (Hi-C, Element, Illumina) read data; 2) in-house generation of reference-grade draft genome assemblies; 3) manual curation of the draft assemblies; 4) submission of the final, curated assemblies to the public archives. The individual will be integrated in step 2, and will be responsible to run, maintain, further develop, and improve the VGL genome assembly pipeline currently implemented in Galaxy (Lariviere et al. 2024 Nature Biotechnology DOI: 10.1038/s41587-023-02100-3). Responsibilities Responsibilities include: • Genome assembly • Genome assembly pipeline maintenance Qualifications The ideal candidate will have a sound knowledge of genomics, ideally with insights into genome assembly, genome curation and genome analysis. Required: • Master's degree required, Ph.D. preferred • Educational emphasis in computer science or computational biology • Strong programming skills, includin knowledge of computational data-analysis workflows (e.g. CWL) • Familiarity with Unix and HPC environments • The ability to work both independently and as part of a team Preferred: • Previous experience with Galaxy workflows is a plus • The ability to organize, prioritize and plan a diverse range of work to meet deadlines • An investigative and solution-orient mindset • Good communication skills • Skilled in working effectively within large national and international scientific consortia The Rockefeller University does not discriminate in employment on the basis of race, color, religion, sex (including pregnancy, gender identity), national origin, political affiliation, sexual orientation, marital status, disability, genetic information, age, membership in an employee organization, retaliation, parental status, military service or other non-merit factor. All qualified applicants will receive consideration for employment without regard to the characteristics listed above. The salary of the finalist selected for this role will be set based on various factors, including but not limited to organizational budgets, qualifications, experience, education, licenses, specialty, and training. The hiring range provided represents The Rockefeller University's good faith and reasonable estimate of the range of possible compensation at the time of posting. Compensation Range: Min USD $62,400.00/Yr. Compensation Range: Max USD $80,000.00/Yr.

Exciting Opportunity at MSK: Are you a Software Engineer enthusiastic about helping solve problems in cancer biology, genomics, and their clinical applications? Join us as a Bioinformatics Software Engineer IV! In this role you will lead the software engineering team who is developing the FDA-recognized precision oncology database OncoKB. OncoKB is an integral component of the clinical genomics platform at MSK, codifying MSK’s immense expertise on genomic biomarkers and their clinical applications. OncoKB is currently being used to annotate all patient sequencing reports at MSK as well as thousands of patients in retrospective cohorts for cancer researchers worldwide. The OncoKB software suite has been developed in-house at MSK since 2013. It includes a curation interface that supports content curation, a public website (oncokb.org) that hosts more than 1000 daily user visits worldwide, as well as a database and API that support real-time annotation of genomic variants identified in cancer patients. To better support clinical decisions and cancer research, we are looking to expand features of all OncoKB components. The Center for Molecular Oncology’s (CMO) mission is to promote precision oncology through genomic analysis to guide the diagnosis and treatment of cancer patients. The CMO brings together clinicians and scientists throughout MSK to conduct large-scale translational research involving molecular characterization of patient tumor specimens to identify genomic features that drive clinical outcomes. Role Overview: • Execute and oversee the systems, programs, and computational aspects of OncoKB. This includes leading the development and implementation of new features, ensuring the platform's stability and scalability, and leading all aspects of data management and integration. • Lead and develop a team of software engineers, providing technical guidance, mentorship, and support. This involves fostering a collaborative and productive work environment, setting clear goals and expectations, and conducting performance reviews. • Collaborate with the OncoKB Lead Scientist and SCMT to translate scientific and clinical requirements into technical specifications. This includes participating in meetings, reviewing documentation, and providing input on the feasibility and implementation of new features. • Lead all aspects of the deployment of OncoKB to its various outputs, including the public website (www.oncokb.org), cBioPortal for Cancer Genomics, and MSK-IMPACT clinical reports. This involves working closely with IT and other collaborators to ensure seamless integration and data transfer. • Ensure the security and integrity of OncoKB data, implementing appropriate access controls, data backup and recovery procedures, and data validation protocols. • Stay abreast of emerging technologies and best practices in software engineering, evaluating and adopting new tools and methodologies to enhance the functionality and performance of the OncoKB platform. Key Qualifications: • Master’s degree with 5 years of experience or Bachelor's degree with 7 years of proven ability in computer science, bioinformatics, or a related field, or equivalent professional experience. • Strong leadership and management skills, with the ability to motivate and guide a team of engineers. • Demonstrated expertise in web application development, including proficiency in HTML5, CSS, Java, and Python. • Extensive experience with databases such as MySQL and MongoDB. • Strong understanding of cloud deployment principles and technologies. • Experience with software development in a team environment using Git/GitHub or other source code control systems. • Excellent communication and collaboration skills, with the ability to effectively interact with scientists, clinicians, and other stakeholders. Core Skills: • Experience with Google Firebase or similar platforms. • Knowledge of user interface design principles and best practices. • Prior experience working on open-source projects related to bioinformatics or cancer genomics. • Familiarity with the principles of precision oncology and cancer variant interpretation. Additional Information: • Schedule: 37.5 hours Monday - Friday, hybrid • Location: 323 E. 61st Street (Maclowe) • Reporting to: Attending Associate Pay Range: $131,800.00-$217,500.00 #LI-hybrid Helpful Links: • MSK Compensation Philosophy • Review Our Greats Benefits Offerings Please click to learn more about MSK’s compensation philosophy.

Description We are seeking a junior bioinformatician for the Tisch Cancer Institute Bioinformatics for Next Generation Sequencing (BiNGS) shared resource facility, to lead genomics, transcriptomics and epigenetics data analysis projects related to Cancer and Developmental biology. The mission of BiNGS is to enhance scholarship and facilitate NGS data analysis in the ISMMS community by providing access to state-of-the-art tools and training. The BiNGS staff support a broad range of biostatistics and bioinformatics analyses for multiple applications spanning bulk ATAC-, RNA-, and ChIP-seq, CUT&RUN and HiC, single cell ATAC- and RNA-seq, single cell Multiome and Spatial Transcriptomics, WGS and WES. BiNGS further provides services for data management, bioinformatics tools development, access to biocomputing resources, web-based app development, and advanced computational training in data analysis. We are focused on delivering a comprehensive, rapid and user-friendly service. More specifically, we are working on multiple projects together with PIs in the Tisch Cancer institute and the broader Mount Sinai community to analyze NGS related datasets. For example, we are working to understand the role of the histone variant MacroH2A in the regulation of chromatin organization in melanoma utilizing micro-C analysis, enhancers analysis, transcriptomic analysis, open chromatin analysis and transcription factor network analysis; in another project, we are working to develop a computational classifier for risk assessments from cancer patients’ biopsies, utilizing WES and ultra-low pass WGS and ML tools. We are seeking a highly motivated junior Bioinformatic Scientist who wants the opportunity to significantly impact the growth and success of our research programs, the bioinformatics core and the services we provide. The candidate will work closely with TCI investigators to facilitate and enhance the processing of their projects. Commitment to accuracy, high attention-to-details, and ability to work independently are critical competencies for the role. The ability to lead projects is a must. We feel that BiNGS presents a unique opportunity for junior bioinformaticians who seek to work with like-minded professionals to expand their data analysis skills; their understanding of transcriptional and epigenetic programs and their role in driving cancer initiation, progression and metastasis, and other diseases; their ability to communicate science clearly and efficiently; and their involvement in reducing racial bias in science through mentorship of URM in Science. Responsibilities • Execute computational analysis for bulk RNA- and ATAC-seq, ChIP-seq, and HiC using existing analysis pipelines. • Integrate data across different datatypes and from publicly available resources (e.g., ENCODE and TCGA), with experimental data generated by PIs. for example; correlation with gene expression signatures, and Histone PTM enrichment analysis. The ideal candidate will be able to navigate the available datasets and extract meaningful data based on the system he/she works on. • Provide analyses and visualization for presentations and publications. • Participate in the implementation of new software tools to process, analyze and visualize high-throughput multidimensional sequencing data. The candidate will be required to identify the main requirements, identify available tools, implement and test. • Manage the core online database and interactive tools on local HPC and commercially available clouds preferably Amazon Web Services. • Tracking and reporting of ongoing projects. • Provide training to TCI investigators and trainees. Qualifications • B.S. in Biological Sciences, Bioinformatics, Computer Sciences, Statistics or related discipline; MSc in Bioinformatics or Computational biology with a focus on genomics or related discipline preferred. • 3 years experience required • Working experience with genetics or statistics analysis software and online resources. Experience in programming environments such as Matlab, R statistical package, BioConductor, Perl or C++. • Experience in analyzing and integrating bulk RNA- and ATAC-seq, ChIP-seq, and HiC datatypes. • Knowledge of cancer biology, chromatin biology, and technologies such as next-generation sequencing. • Proven experience with Perl, R and Unix. Additional experience with standard genomics tools for high-throughput sequencing data analysis is preferred (e.g., Bowtie2, deepTools, Samtools, and the UCSC genome browser). • Experience in batch HPC cluster environment with a parallel file system. • Ability to research, analyze, recommend, communicate and implement data analysis solutions. • Must be able to work as an individual while part of a small team. Employer Description Strength Through Diversity The Mount Sinai Health System believes that diversity, equity, and inclusion are key drivers for excellence. We share a common devotion to delivering exceptional patient care. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education, and advancement as we revolutionize medicine together. We invite you to participate actively as a part of the Mount Sinai Health System team by: • Using a lens of equity in all aspects of patient care delivery, education, and research to promote policies and practices to allow opportunities for all to thrive and reach their potential. • Serving as a role model confronting racist, sexist, or other inappropriate actions by speaking up, challenging exclusionary organizational practices, and standing side-by-side in support of colleagues who experience discrimination. • Inspiring and fostering an environment of anti-racist behaviors among and between departments and co-workers. At Mount Sinai, our leaders strive to learn, empower others, and embrace change to further advance equity and improve the well-being of staff, patients, and the organization. We expect our leaders to embrace anti-racism, create a collaborative and respectful environment, and constructively disrupt the status quo to improve the system and enhance care for our patients. We work hard to create an inclusive, welcoming and nurturing work environment where all feel they are valued, belong and are able to advance professionally. Explore more about this opportunity and how you can help us write a new chapter in our history! “About the Mount Sinai Health System: Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes approximately 7,400 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 14 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally. The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism.” EOE Minorities/Women/Disabled/Veterans Compensation The Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $65000 - $83430 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.

Research Associate in Bioinformatics within ITMAT Location: Philadelphia, PA Open Date: Mar 11, 2024 Deadline: Mar 11, 2026 at 11:59 PM Eastern Time The Institute for Translational Medicine and Therapeutics at the Perelman School of Medicine at the University of Pennsylvania seeks candidates for a Research Associate position in the Academic Support Staff. This appointment will be initially for one (1) year and continuation during that time period and renewal are based on satisfactory performance and availability of funding (limited to three (3) years). Expertise is required in the specific area of Bioinformatics, Computational Biology, Computer Science, Statistics, Mathematics or closely related field. Applicants must have a Ph.D. degree. Responsibilities may include • Research in bioinformatics, which includes: - designing, architecting, developing, and testing software for managing and processing big data sets obtained from various biological experiments - investigating and benchmarking published bioinformatics software and tools - investigating high performance computing and cloud platforms for running bioinformatics software and tools - development of novel methods for statistical and/or machine learning analysis of omics data • Computational and statistical support for studies performed by ITMAT researchers, which includes: - management and processing of big data sets obtained by next generation high throughput sequencing - statistical and machine learning analysis of processed data - integration of heterogeneous (transcriptomics, epigenomics, proteomics, metabolomics, i.e., omics) data sets using statistical and machine learning techniques - development of methods for manipulation and visualization of omics data • Participation in various seminars, colloquia, and conferences • Occasional light teaching assignments. The successful applicant will have an opportunity to primarily carry out a research program under the direction of Dr. Gregory Grant. The position will also allow the candidate to grow as an independent scientist and gain eligibility to apply for funding through different mechanisms. We seek candidates who embrace and reflect diversity in the broadest sense. The University of Pennsylvania is an EOE. Minorities/women/individuals with disabilities/protected veterans are encouraged to apply. Qualifications Application Instructions To apply, visit https://apply.interfolio.com/142410 The University of Pennsylvania values diversity and seeks talented students, faculty and staff from diverse backgrounds. The University of Pennsylvania is an equal opportunity and affirmative action employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status or any other legally protected class. Questions or concerns about this should be directed to the Executive Director of the Office of Affirmative Action and Equal Opportunity Programs, University of Pennsylvania, 421 Franklin Building, 3451 Walnut Street, Philadelphia, PA 19104-6205; or (215) 898-6993 (Voice) or (215) 898-7803 (TDD). jeid-7f37d4c556a0d04cbd4331448706b8a2

SHIFT: Day (United States of America) Seeking Breakthrough Makers Children’s Hospital of Philadelphia (CHOP) offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation. At CHOP, your experience is valued; your voice is heard; and your contributions make a difference for patients and families. Join us as we build on our promise to advance pediatric care—and your career. CHOP’s Commitment to Diversity, Equity, and Inclusion CHOP is committed to building an inclusive culture where employees feel a sense of belonging, connection, and community within their workplace. We are a team dedicated to fostering an environment that allows for all to be their authentic selves. We are focused on attracting, cultivating, and retaining diverse talent who can help us deliver on our mission to be a world leader in the advancement of healthcare for children. We strongly encourage all candidates of diverse backgrounds and lived experiences to apply. A Brief Overview The Genomic Diagnostic Laboratory (GDL) of the Children’s Hospital of Philadelphia is seeking a highly motivated Supervisory Bioinformatics Scientist to manage our Bioinformatics team consisting of Bioinformatics Scientists, Bioinformatics Engineers, and RIA Programmers. This is an exciting opportunity to join our laboratory where we use a wide variety of molecular and cytogenetic test methodologies to provide accurate, timely diagnostic testing that has a direct impact on patient care. The team also supports cutting edge R&D efforts including new clinical test development and clinical research. The Supervisory Bioinformatics Scientist is a key member of the leadership team in the GDL, collaborating with other lab leaders including the Director of Bioinformatics, clinical directors, managers, and supervisors). The successful candidate will have a strong human genetics, bioinformatics, and management background that will be applied to training, clinical work, R&D, and troubleshooting. Good documentation practices as well as strong organizational and communication skills are essential. Job responsibilities include scheduling work duties, providing semi-annual performance reviews, assuring that all accreditation requirements are in full compliance, and participating in quality improvement initiatives. We seek a leader who has an interest in strategic planning to develop and improve our bioinformatics pipelines and other tools to support our expanding test menu. This position can be worked fully on-site at our campus in Philadelphia, PA, or as a hybrid role with an expectation of on-site presence at least once a week, and additional on-site presence possible based on the needs of the lab. In addition to many of the subject matter expert responsibilities of the Principal Bioinformatics Scientist, the Supervisory Bioinformatics Scientist will also: • Build and supervise a team responsible for the architecture, development, testing and production rollout of integrated biomedical data resources and applications. • Balance competing priorities and resource allocation across a portfolio of matrixed projects and collaborations. • Promote common standards and best-practice use of multiple technologies to create innovative solutions that have a high impact on data-intensive clinical and translational research. • Serves as the data integration team lead on larger complex projects that include informatics, clinical and translational researchers. • Propose staffing plans for multi-year strategic data resource initiatives. • Train, mentor, and hold junior staff accountable to the results of modern technology development methodologies such as code test coverage, continuous integration, monitoring. • Educate staff, students, and trainees (fellows, post-docs) on appropriate staffing and expertise levels for application of data integration methods in the clinical and translational research environment. What you will do • A Supervisory Bioinformatics Scientist functions as both subject matter expert and team manager. The responsibilities echo those of a Principal Bioinformatics Scientist, but include direct supervision of team members and projects. A Supervisory Bioinformatics Scientist will: • Directly lead and mentor junior staff in a direct supervisory capacity. • Guide and develop the skills and expertise of junior staff • Build project budgets by estimating time and effort costs • Hold data integration and technical teams accountable to high-level project goals and timelines, mapping detailed project plans into these timelines. • Recruit, hire, and retain a focused team of any of Bioinformatics Scientists, Bioinformatics Engineers, and Bioinformatics Programmers. • Provide bioinformatics academic and thought leadership for joint collaborations with CHOP PIs. Education Qualifications • Master's Degree Required • Doctorate Bioinformatics, Computational Biology, Computer Science, Information Science, Informatics, Biomedical Engineering, Biological Science or a related discipline Preferred Experience Qualifications • At least seven (7) years Experience in bioinformatics analysis, bioinformatics database development, bioinformatics database administration, bioinformatics data management, or related discipline, with progressively more complex projects in a biomedical science or healthcare environment. Required • At least one (1) year Small team supervisory experience. Required Skills and Abilities • Experience in bioinformatics and statistical data analysis on highly dimensional data types such as derived from genomics and observational clinical or human subjects research data. • Expert knowledge of relational database management systems such as PostgreSQL, MySQL, Oracle required. • Expert knowledge of bioinformatics applications and algorithms. • Expert knowledge of one or more of the following required: Python/Django, R, Perl, Scala, Ruby or other scripting languages. • Expert biological domain knowledge. • Must exhibit excellent oral, presentation, and written communication skills. • Experience with source code management, application development, and project lifecycle management. • Project management experience of complex matrix projects required. • Proficiency in the areas of bioinformatics analysis, statistical modeling, data integration, and bioinformatics thought leadership in the larger biomedical community. To carry out its mission, CHOP is committed to supporting the health of our patients, families, workforce, and global community. As a condition of employment, CHOP employees who work in patient care buildings or who have patient facing responsibilities must be fully vaccinated against COVID-19 and receive an annual influenza vaccine. Learn more. Employees may request exemptions for valid religious and medical reasons. Start dates may be delayed until candidates are immunized or exemption requests are reviewed. EEO / VEVRAA Federal Contractor | Tobacco Statement