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Manager, Bioinformatics
This a Full Remote job, the offer is available from: Asia, India Welcome to the era of Velsera! Seven Bridges, Pierian & UgenTec have combined to become Velsera. Velsera is the precision engine company. We empower researchers, scientists, and clinicians to drive precision R&D, expand access to, and more effectively leverage analytics at the point of care. We unify technology-enabled solutions and scientific expertise to enable a continuous flow of knowledge across the global healthcare ecosystem. This interweaves diverse biomedical communities, allowing them to build upon each other’s success and accelerate medical breakthroughs that positively impact human health. With our headquarters in Boston, MA, we are growing and expanding our team which located in 14 different countries! What will you do? • Subject matter expert in guiding, reviewing and ensuring the quality of team member deliverables • Responsible for different aspects of team performance - both scientific and operational • Responsible for quality of the team deliverables • Responsible for project assignment to team members • Ensure optimal performance of team members, resolving conflicts and removing blockers or escalating in timely manner • Set individual goals for team members and coach them towards achieving them • Coach and mentor team members in order to enable their timely career advancement to more senior positions (relative to their current) • Provide regular feedback to team members and supports their development within the company • One of the main stakeholders in the hiring effort What do you bring to the table? • BSc with minimum 4 years of experience in relevant domain or MSc with minimum 3 years of experience in relevant domain • Minimum of 3 years of relevant experience • Good programing skills and bioinformatic knowledge with focus on R, NextFlow, Rshiny, CWL, Python • Good communication and interpersonal skills • 2+ years of experience in mentoring and guiding younger colleagues • People management and development experience • Advanced knowledge of programming and good programming practices What do we offer? Velsera stands for a stimulating atmosphere where you can grow your capabilities in an open company culture. We want you to do the work you feel great at, or that you would like to become great at. You’ll work for a mission driven organization that is making a true difference in the scientific and healthcare space. Next to that, we offer competitive salaries including: • A full-suite of industry leading benefits (list by location) • Remote work flexibility If you feel like this could be the next big thing for you, make sure you’re not going to miss out and have a chat with us! Competencies Decisiveness The ability to make active decisions or to commit oneself by speaking one’s mind and taking position. • Makes decisions that affect other departments, units, clusters • Makes decisions that promote efficiency and effectiveness of their own and other departments • Translates policy into actions for their department, taking other departments into account • Makes decisions and takes actions that solve recurrent problems • Takes up a position in meetings that reflects a super-departmental point of view Managing The ability to manage and take charge of employees in order to enhance their performance; defining targets and providing appropriate means; controlling progress and correcting employees. • Provides adequate resources, facilities and conditions for an effective work process • Translates strategic goals into practical, feasible activities (strategic plan) • Motivates employees to come up with their own contributions and solutions • Encourages employees to look beyond their own department in order to enhance the organization's development • Leads by example and advocates any desired change Developing Employees The ability to review and analyze employees’ strengths and weaknesses, to distinguish their talents and development needs, and to make sure they are enhanced appropriately. • Makes an inventory of employees' talents and qualities • Surveys the knowledge and experience needed in the department or team for the years to come • Distinguishes talents and lets them sign up for management development courses • Lets employees draft their own personal development plans • Offers employees the opportunity to gain more experience through job rotation and projects Our Core Values People first. We create collaborative and supportive environments by operating with respect and flexibility to promote mental, emotional and physical health. We practice empathy by treating others the way they want to be treated and assuming positive intent. We are proud of our inclusive diverse team and humble ourselves to learn about and build our connection with each other. Patient focused. We act with swift determination without sacrificing our expectations of quality. We are driven by providing exceptional solutions for our customers to positively impact patient lives. Considering what is at stake, we challenge ourselves to develop the best solution, not just the easy one. Integrity. We hold ourselves accountable and strive for transparent communication to build trust amongst ourselves and our customers. We take ownership of our results as we know what we do matters and collectively we will change the healthcare industry. We are thoughtful and intentional with every customer interaction understanding the overall impact on human health. Curious. We ask questions and actively listen in order to learn and continuously improve. We embrace change and the opportunities it presents to make each other better. We strive to be on the cutting edge of science and technology innovation by encouraging creativity. Impactful. We take our social responsibility with the seriousness it deserves and hold ourselves to a high standard. We improve our sustainability by encouraging discussion and taking action as it relates to our natural, social and economic resource footprint. We are devoted to our humanitarian mission and look for new ways to make the world a better place. Velsera is an Equal Opportunity Employer: Velsera is proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, colour, gender, religion, marital status, domestic partner status, age, national origin or ancestry. This offer from "Velsera" has been enriched by Jobgether.com and got a 77% flex score.
Bioinformatics Engineer, Associate (Remote)
Overview Haystack Oncology at Quest Diagnostics is seeking to grow its laboratory informatics team as we expand our assay portfolio and introduce cutting edge diagnostic technology to the public. As a Bioinformatics Engineer - LIMS, you will be responsible for developing, configuring, maintaining, and optimizing key functionality within our cloud-based enterprise Laboratory Information Management System (LIMS) that manages the generation, analysis, quality control, and interpretation of clinical data produced by diagnostic NGS assays. The ideal candidate will possess technical development experience within a LIMS platform, a rounded understanding of clinical laboratory processes and FDA regulations, strong analytical and problem-solving skills and a collaborative and continuous improvement mindset. This is a salaried position and weekend work may be required to satisfy project timelines and to support end-users. This position can work 100% remote and may require up to 10% travel as needed. Professional must be located in the US and is expected to be available during normal business hours in the Eastern and Central US time zones in order to provide support for laboratory sites in these regions. Responsibilities • Work extensively within our cloud-based StarLIMS system to develop and configure frontend and backend solutions that further automate our scientific and technical processes. • Develop new or modify existing code using StarLIMS scripting languages, HTML5, Jscript, .NET libraries, and Python following industry best practices. • Develop scientific reports using SQL, Crystal Reports, and StarLIMS QBE. • Gather and analyze requirements provided by cross functional stakeholders and translate into functional requirements that allow for the development of technical solutions. • Manage workload in Jira and provide timely and accurate status updates on project-based issue tickets that are either assigned or self-assigned. • Document system configurations, procedures, and any changes for reference and compliance purposes. • Both individually and as a part of a team, troubleshoot, debug, and test technical solutions • Provide ongoing support and training to laboratory staff and stakeholders on LIMS usage and best practices. • Respectfully and clearly communicate in English both textually and verbally with stakeholders. • Other duties, as assigned, that will contribute to the success of our company and the data systems we deploy. Qualifications • Bachelors' or greater degree in Bioinformatics, Computer Science or other STEM-related disciplines. • Minimum 3 years of experience in the configuration and customization of an enterprise LIMS system is required. Experience with StarLIMS is preferred. • Minimum 3 years of experience in the development of custom code using scripting and/or programming languages. • Minimum 3 years of experience with relational databases and reporting tools, including Crystal Reports. • Experience with system integration techniques including REST APIs, web services, and middleware. • Strong understanding of laboratory workflows, data management, and compliance standards. • Experience with laboratory testing and scientific equipment. • Professional experience with a bug/issue tracking system. • Understanding of software design controls and SDLC. • Ability to work effectively with minimal direct supervision in a multiple discipline environment. • Ability to manage multiple tasks and assignments simultaneously. • Ability to adapt quickly to changing priorities in a fast-paced environment. • Excellent analytical, troubleshooting and problem-solving abilities. Proficient in diagnosing and providing solutions for bugs and issues. • Excellent communication and interpersonal skills, both verbal and written in English, with the ability to translate technical information for non-technical stakeholders. • Certificates in IT related topics are a plus. Education:Bachelor’s Degree(Required)Master’s Degree EEO Equal Opportunity Employer: Race/Color/Sex/Sexual Orientation/Gender Identity/Religion/National Origin/Disability/Vets
10101 - Bioinformatics Analyst & Coordinator
Bioinformatics Analyst & Coordinator The Fund for Public Health in New York City (FPHNYC) is a 501(c)3 non-profit organization that is dedicated to the advancement of the health and well-being of all New Yorkers. To this end, in partnership with the New York City Department of Health and Mental Hygiene (DOHMH), FPHNYC incubates innovative public health initiatives implemented by DOHMH to advance community health throughout the city. It facilitates partnerships, often new and unconventional, between the government and the private sector to develop, test, and launch new initiatives. These collaborations speed the execution of demonstration projects, effect expansion of successful pilot programs, and support rapid implementation to meet the public health needs of individuals, families, and communities across New York City. PROGRAM OVERVIEW The Public Health Laboratory (PHL) mission is to ensure the health of all New York City (NYC) residents by providing quality laboratory testing services that address the needs of the NYC DOHMH and its community partners as they respond to clinical and environmental public health concerns. POSITION OVERVIEW This position will serve as a Bioinformatics analyst & coordinator at the PHL and be involved with sequencing and data management activities within the bureau. RESPONSIBILITIES Support onboarding pipelines & data management for current and emerging pathogens such as Tuberculosis, Carbapenem-resistant organisms, and other pathogens. This requires strong skills in BASH shell scripting and R. Python and SQL are good to have skills. Manage the packaging and publishing of genomic sequences to public repositories such as NCBI and GISAID. Lead and/or support the data unit in maintaining meta-data datasets for genomic sequences. Coordinate the implementation and enhancements of high throughput sequencing and bioinformatics projects. Participate in analytical activities as needed to support outbreak investigations and routine surveillance. Perform research to identify and implement new analytical tools and visualization methods. Assist with progress reports to ensure projects run smoothly. Liaise between units and sections at PHL to identify, prioritize, and finalize goals for pathogen sequencing. Lead efforts to improve sustainable data management and tracking across multiple units and bureaus. Communicate effectively with lab technologists and analysts as well as internal and external partners. Evaluate data, prepare reports, maintain records, and assist in the coordination of research efforts of the Agency. Maintain and participate in a quality control and assurance program as required by job functions and title assignments in the laboratory. Recognize, troubleshoot, and initiate corrective action for problems in a timely manner. Participate in writing original manuscripts for publication based on data analyses. QUALIFICATIONS Master’s degree in Biological science or Bioinformatics. Knowledge of biology, high throughput sequencing, and bioinformatics are highly desired. Strong verbal and written communication skills. Ability to work well within a management team environment. Excellent project management skills and familiarity with project management tools. Excellent interpersonal communication skills. SALARY Salary range is $90,000 to $95,000 WORK SCHEDULE 9:00 am – 5:00 pm Monday through Friday In-office BENEFITS AT A GLANCE FPHNYC offers a comprehensive benefits package Generous Paid Time Off (PTO) policy Medical, dental, and life insurance with low or no employee contribution A retirement savings plan with generous employer contribution Flexible spending medical and commuter benefits plan Meaningful work at an organization striving to advance health equity and social justice RESIDENCY REQUIREMENT You must live in New York City Tri-state area (NY, NJ, CT) in order to be considered for a position at FPHNYC. TO APPLY To apply, upload Resume, including how your experience relates to this position. Applicants who best match the position needs will be contacted. The Fund for Public Health in New York City is an Equal Opportunity Employer and encourages a diverse pool of candidates to apply.
Research Scientist- Computational Biology
No Relocation Assistance Offered # 163309 - Piscataway, New Jersey, United States Who We Are Colgate-Palmolive Company is a caring, innovative growth company that is reimagining a healthier future for all people, their pets and our planet. Focused on Oral Care, Personal Care, Home Care and Pet Nutrition, we sell our products in more than 200 countries and territories under brands such as Colgate, Palmolive, elmex, hello, meridol, Sorriso, Tom’s of Maine, EltaMD, Filorga, Irish Spring, PCA SKIN, Protex, Sanex, Softsoap, Speed Stick, Ajax, Axion, Fabuloso, Soupline and Suavitel, as well as Hill’s Pet Nutrition. We are recognized for our leadership and innovation in promoting sustainability and community wellbeing, including our achievements in decreasing plastic waste and promoting recyclability, saving water, conserving natural resources and improving children’s oral health. If you want to work for a company that lives by their values, then give your career a reason to smile and join our global team! Colgate-Palmolive is seeking a highly motivated scientist with a track record of excellence for a position in Global R&D, Skin Research & Innovation group, based in Piscataway, NJ. What you will do • Design and investigate biological changes in skin, particularly utilizing omics. • Perform comprehensive and detailed analysis from omics related skin data, including but not limited to RNA-seq, spatial transcriptomics, single cell sequencing (scRNAseq), proteomics, metabolomics and epigenetic datasets. • Utilizing design and implementation tools and various applications to support skin health research; apply machine learning models to improve data analysis. • Extract meaningful biological insights from complex datasets, integrating findings with existing biological knowledge and systems biology, and collaborate to validate results • Interpret findings through presentation and data visualizations to internal partners and contribute to scientific publications. Required Qualifications • Bachelor's Degree with 5+ years experience in the Bioinformatics or Masters in Biology/Chemistry with 2+ years in Bioinformatics with a skin biology background • Hands-on experience on evaluation of bioinformatics projects • Knowledge of computational models and machine learning Preferred Qualifications • Ph.D. in Bioinformatics w. 2+ yrs of experience • Hands on experience with human skin cell/tissue culture (keratinocytes, fibroblasts, skin equivalents and explants) • Strong problem solving skills, project management and execution skills • Excellent communication and collaboration skills Compensation and Benefits Salary Range $110.000,00 - $128.000,00 USD Pay is based on multiple non-discriminatory, individualized factors including but not limited to experience, job-related knowledge and education, skills and office/market location. In addition to base salary, salaried employees are eligible for annual discretionary bonuses, profit-sharing and, for Executive-level (salary grade 16 and above) roles only, long-term incentives in the form of Restricted Stock Units and/or Stock Options. Subject to the terms and conditions of the applicable benefits plans then in effect, all salaried employees are also eligible for a competitive benefits package which includes: • Insurance: Employees (and their eligible dependents) are eligible to participate in Company-sponsored Medical, Dental, Vision, Basic Life Insurance, Accidental Death & Dismemberment and Disability insurance plans. • Retirement Plans: Employees are eligible to enroll in Colgate's 401(k) plan, which provides for company matching contributions subject to eligibility requirements • Vacation/PTO: Employees receive a minimum of 15 days of vacation/PTO leave annually • Paid Holidays: Employees receive a minimum of 13 paid/floating holidays annually • Paid Sick Leave: Based on location and consistent with applicable state and local law, employees receive a minimum of 40 hours of paid sick leave on January 1st of each year • Paid Parental Leave: Eligible employees may take up to eight weeks of paid parental leave and 12 weeks of unpaid leave (varies for employees with fewer than 12 months of service and is subject to hours worked requirements) Our Commitment to Sustainability With the Colgate brand in more homes than any other, we are presented with great opportunities and new challenges as we work to integrate sustainability into all aspects of our business and create positive social impact. We are determined to position ourselves for further growth as we act on our 2025 Sustainability & Social Impact Strategy. Our Commitment to Diversity, Equity & Inclusion Achieving our purpose starts with our people — ensuring our workforce represents the people and communities we serve —and creating an environment where our people feel they belong; where we can be our authentic selves, feel treated with respect and have the support of leadership to impact the business in a meaningful way. Equal Opportunity Employer Colgate is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, ethnicity, age, disability, marital status, veteran status (United States positions), or any other characteristic protected by law. Reasonable accommodation during the application process is available for persons with disabilities. Please contact Application_Accommodation@colpal.com with the subject "Accommodation Request" should you require accommodation. For additional Colgate terms and conditions, please click here. #LI-Hybrid
Bioinformatics Analyst & Coordinator
The Fund for Public Health in New York City (FPHNYC) is a 501(c)3 non-profit organization that is dedicated to the advancement of the health and well-being of all New Yorkers. To this end, in partnership with the New York City Department of Health and Mental Hygiene (DOHMH), FPHNYC incubates innovative public health initiatives implemented by DOHMH to advance community health throughout the city. It facilitates partnerships, often new and unconventional, between the government and the private sector to develop, test, and launch new initiatives. These collaborations speed the execution of demonstration projects, effect expansion of successful pilot programs, and support rapid implementation to meet the public health needs of individuals, families, and communities across New York City. Program Overview The Public Health Laboratory (PHL) mission is to ensure the health of all New York City (NYC) residents by providing quality laboratory testing services that address the needs of the NYC DOHMH and its community partners as they respond to clinical and environmental public health concerns. Position Overview This position will serve as a Bioinformatics analyst & coordinator at the PHL and be involved with sequencing and data management activities within the bureau. Responsibilities • Support onboarding pipelines & data management for current and emerging pathogens such as Tuberculosis, Carbapenem-resistant organisms, and other pathogens. This requires strong skills in BASH shell scripting and R. Python and SQL are good to have skills. • Manage the packaging and publishing of genomic sequences to public repositories such as NCBI and GISAID. • Lead and/or support the data unit in maintaining meta-data datasets for genomic sequences. • Coordinate the implementation and enhancements of high throughput sequencing and bioinformatics projects. • Participate in analytical activities as needed to support outbreak investigations and routine surveillance. • Perform research to identify and implement new analytical tools and visualization methods. • Assist with progress reports to ensure projects run smoothly. • Liaise between units and sections at PHL to identify, prioritize, and finalize goals for pathogen sequencing. • Lead efforts to improve sustainable data management and tracking across multiple units and bureaus. • Communicate effectively with lab technologists and analysts as well as internal and external partners. • Evaluate data, prepare reports, maintain records, and assist in the coordination of research efforts of the Agency. • Maintain and participate in a quality control and assurance program as required by job functions and title assignments in the laboratory. • Recognize, troubleshoot, and initiate corrective action for problems in a timely manner. • Participate in writing original manuscripts for publication based on data analyses. QUALIFICATIONS • Master’s degree in Biological science or Bioinformatics. • Knowledge of biology, high throughput sequencing, and bioinformatics are highly desired. • Strong verbal and written communication skills. Ability to work well within a management team environment. • Excellent project management skills and familiarity with project management tools. • Excellent interpersonal communication skills. SALARY • Salary range is $90,000 to $95,000 WORK SCHEDULE 9:00 am – 5:00 pm Monday through Friday In-office Benefits At a Glance FPHNYC offers a comprehensive benefits package • Generous Paid Time Off (PTO) policy • Medical, dental, and life insurance with low or no employee contribution • A retirement savings plan with generous employer contribution • Flexible spending medical and commuter benefits plan • Meaningful work at an organization striving to advance health equity and social justice RESIDENCY REQUIREMENT You must live in New York City Tri-state area (NY, NJ, CT) in order to be considered for a position at FPHNYC. TO APPLY To apply, upload Resume, including how your experience relates to this position. Applicants who best match the position needs will be contacted. The Fund for Public Health in New York City is an Equal Opportunity Employer and encourages a diverse pool of candidates to apply. Apply Now
Bioinformatics Engineer, Associate (Remote)
Haystack Oncology at Quest Diagnostics is seeking to grow its laboratory informatics team as we expand our assay portfolio and introduce cutting edge diagnostic technology to the public. As a Bioinformatics Engineer - LIMS, you will be responsible for developing, configuring, maintaining, and optimizing key functionality within our cloud-based enterprise Laboratory Information Management System (LIMS) that manages the generation, analysis, quality control, and interpretation of clinical data produced by diagnostic NGS assays. The ideal candidate will possess technical development experience within a LIMS platform, a rounded understanding of clinical laboratory processes and FDA regulations, strong analytical and problem-solving skills and a collaborative and continuous improvement mindset. This is a salaried position and weekend work may be required to satisfy project timelines and to support end-users. This position can work 100% remote and may require up to 10% travel as needed. Professional must be located in the US and is expected to be available during normal business hours in the Eastern and Central US time zones in order to provide support for laboratory sites in these regions. • Work extensively within our cloud-based StarLIMS system to develop and configure frontend and backend solutions that further automate our scientific and technical processes. • Develop new or modify existing code using StarLIMS scripting languages, HTML5, Jscript, .NET libraries, and Python following industry best practices. • Develop scientific reports using SQL, Crystal Reports, and StarLIMS QBE. • Gather and analyze requirements provided by cross functional stakeholders and translate into functional requirements that allow for the development of technical solutions. • Manage workload in Jira and provide timely and accurate status updates on project-based issue tickets that are either assigned or self-assigned. • Document system configurations, procedures, and any changes for reference and compliance purposes. • Both individually and as a part of a team, troubleshoot, debug, and test technical solutions • Provide ongoing support and training to laboratory staff and stakeholders on LIMS usage and best practices. • Respectfully and clearly communicate in English both textually and verbally with stakeholders. • Other duties, as assigned, that will contribute to the success of our company and the data systems we deploy. • Bachelors' or greater degree in Bioinformatics, Computer Science or other STEM-related disciplines. • Minimum 3 years of experience in the configuration and customization of an enterprise LIMS system is required. Experience with StarLIMS is preferred. • Minimum 3 years of experience in the development of custom code using scripting and/or programming languages. • Minimum 3 years of experience with relational databases and reporting tools, including Crystal Reports. • Experience with system integration techniques including REST APIs, web services, and middleware. • Strong understanding of laboratory workflows, data management, and compliance standards. • Experience with laboratory testing and scientific equipment. • Professional experience with a bug/issue tracking system. • Understanding of software design controls and SDLC. • Ability to work effectively with minimal direct supervision in a multiple discipline environment. • Ability to manage multiple tasks and assignments simultaneously. • Ability to adapt quickly to changing priorities in a fast-paced environment. • Excellent analytical, troubleshooting and problem-solving abilities. Proficient in diagnosing and providing solutions for bugs and issues. • Excellent communication and interpersonal skills, both verbal and written in English, with the ability to translate technical information for non-technical stakeholders. • Certificates in IT related topics are a plus. Education: Bachelor’s Degree(Required) Master’s Degree Equal Opportunity Employer: Race/Color/Sex/Sexual Orientation/Gender Identity/Religion/National Origin/Disability/Vets
Bioinformatician II - Nephrology (CPMG)
• Job Type: Officer of Administration • Regular/Temporary: Regular • Hours Per Week: 35 • Salary Range: $85,000 - $95,000 The salary of the finalist selected for this role will be set based on a variety of factors, including but not limited to departmental budgets, qualifications, experience, education, licenses, specialty, and training. The above hiring range represents the University's good faith and reasonable estimate of the range of possible compensation at the time of posting. Position Summary We are seeking a highly motivated bioinformatician to join our innovative research team at the Center for Precision Medicine and Genomics (CPMG). Our mission is to revolutionize healthcare through the integration of personalized medicine into clinical practice. We collaborate closely with clinicians, research scientists, and genetic counselors to drive groundbreaking research and translate genomic discoveries into improved patient outcomes. The ideal candidate will be a skilled bioinformatician with a passion for leveraging genomic data to address complex biomedical challenges. You will contribute to a dynamic, interdisciplinary environment and collaborate with researchers from Columbia University and beyond on a variety of national and international projects. This position offers the opportunity to make a significant impact on the field of precision medicine. Responsibilities • Bioinformatics Analysis (40%): Provide comprehensive bioinformatics support for genomic data analysis, including sequence analysis, pipeline optimization, and data management. Utilize both cloud-based and on-premise computational resources (e.g., exome, genome, RNAseq). Collaborate with team members to ensure efficient data access, analysis, and interpretation. • Communication and Dissemination (20%): Effectively communicate complex bioinformatics findings to both technical and non-technical audiences through presentations, reports, and publications. Collaborate with researchers from diverse backgrounds to translate bioinformatics insights into actionable knowledge. • Workflow Development (20%): Design, develop, and optimize bioinformatics workflows and pipelines to efficiently process and analyze large-scale genomic datasets. Explore innovative approaches to data visualization, exploration, and mining. • Mentorship and Collaboration (20%): Mentor junior team members, including students and post-docs, in bioinformatics techniques and research methodologies. Collaborate with researchers across disciplines to drive successful research projects and grant applications. • Perform additional related duties and responsibilities as needed. Minimum Qualifications • Bachelor's degree in computer science, bioinformatics, or a related field with at least four years of relevant experience. • Master's or Doctoral degree in related field would substitute for experience. • Proficiency in programming languages such as R, Python, and Bash. • Strong communication and interpersonal skills. Preferred Qualifications • Master’s or PhD degree in computer science, bioinformatics, or a related field with at least two years of relevant experience. • Expertise in workflow management tools (e.g., CWL, Nextflow, WDL) and cloud computing platforms (AWS, GCP, Azure). • Advanced knowledge of statistical and machine learning techniques. Other Requirements • Successful completion of applicable compliance and systems training requirements. Equal Opportunity Employer / Disability / Veteran Columbia University is committed to the hiring of qualified local residents.
Bioinformatics Assistant II | Laboratory of Systems Cancer Biology
Organization Overview Cancer remains a daunting problem despite decades of active research into its molecular causes. Such studies have predominantly focused on the earliest stages of cancer progression,such as the formation of a cancer or genes involved in the growth of the primary tumor. In humans afflicted by cancer,the primary tumor is typically surgically resected or eliminated by radiation. Vast numbers of patients,nonetheless,die of cancer as a result of metastasis or the spread of cancer cells from the primary tumor site to distal organs. This process is,in fact,the overwhelming cause of death from cancer,and its occurrence changes a patient's prognosis to incurable. Despite its vast clinical significance and inherently fascinating underlying biology,the metastatic program is poorly understood both at the molecular level and at the cellular/tissue micro-environment levels. Our laboratory employs a multi-disciplinary approach involving molecular,biochemical,computational,imaging,and clinical association methods to characterize the critical regulatory pathways that mediate the steps of this process. By implanting human cancer cells obtained from patients with breast or colon cancer into recipient mice,we study and interfere with the various stages of metastasis. By comparing human cancer cells that are highly metastatic to those that fail to metastasize,we have uncovered a set of small RNA molecules (microRNAs) that suppress metastasis. Our future work is aimed at gaining a better understanding of the mechanisms by which these microRNAs block metastasis. Our hope is that a better understanding of this process will enhance our therapeutic arsenal against it. Overview As a Bioinformatics Assistant II, you will be trained in the analysis and interpretation of next-generation sequencing (NGS) data, originating from mouse experiments of cancer metastasis as well as patients, under the guidance of postdoctoral scientists and bioinformaticians. Responsibilities Responsibilities include: • Learn and assist in analyzing sequencing data using established pipelines • Learn and perform appropriate QC measures • Learn and develop/benchmark new tools for sequencing data analysis • Assist and collaborate with internal and external researchers in interpretation of sequencing data • Other responsibilities, as assigned Qualifications Requirements: • Bachelor's degree is required; Master's degree or equivalent experience preferred • Team-oriented • Excellent written and verbal communication skills • Collaboration skills and an eagerness to learn • A working understanding of code and script Preferred: • Exposure to NGS data analysis preferred • Training in statistics or machine learning is a plus. The Rockefeller University does not discriminate in employment on the basis of race, color, religion, sex (including pregnancy, gender identity), national origin, political affiliation, sexual orientation, marital status, disability, genetic information, age, membership in an employee organization, retaliation, parental status, military service or other non-merit factor. All qualified applicants will receive consideration for employment without regard to the characteristics listed above. The salary of the finalist selected for this role will be set based on various factors, including but not limited to organizational budgets, qualifications, experience, education, licenses, specialty, and training. The hiring range provided represents The Rockefeller University's good faith and reasonable estimate of the range of possible compensation at the time of posting. Compensation Range: Min USD $55,000.00/Yr. Compensation Range: Max USD $65,000.00/Yr.
Bioinformatics Analyst
POSITION RESPONSIBILITIES We are looking for a motivated and experienced Bioinformatics Analyst to join Dr. Robert Burk’s research group. This role is critical for supporting our ongoing research projects focused in 2 areas- the human microbiome (gut, oral and cervicovaginal), and human papillomavirus related to cervix neoplasia. The ideal candidate will have a background in epidemiology, computer science, bioinformatics, or related disciplines, with practical demonstrated experience in processing next-generation sequencing (NGS) data. The successful candidate will demonstrate a willingness and eagerness to adapt to new approaches, as the field of bioinformatics is dynamic and constantly evolving. Key Responsibilities in order of priority: • NGS Data Handling: Perform demultiplexing and analysis of NGS data using barcoding primers for multiplex NGS runs. • Practical Experience: The candidate is expected to have practical experience with bioinformatics work (handling NGS reads off the machine, etc.) and be willing and eager to adapt to new approaches. This role will be facilitated with a proactive attitude towards learning and applying new bioinformatics methods and technologies. • Data Processing and Analysis: Utilize existing pipelines to process and analyze high-throughput sequencing data reads, including amplicon sequencing, bisulfite sequencing, metagenomics, and viral integration. • Data Management: Manage and organize bioinformatics sequencing data for our research group, including papillomavirus sequences, microbiome data (16S, ITS1 and shotgun metagenomics), and human genomic data. • Large Dataset Management: Download and handle large Fastq, BAM, and/or Fasta files for analyses. • Software Utilization and Script Modification: Use existing software tools and be able to modify R scripts to generate figures and perform epidemiological analyses. • Phylogenetic Analysis: Construct phylogenetic trees to support ongoing research projects. • Collaboration and Reporting: Work closely with and report directly to Robert D. Burk, M.D., Principal Investigator, and collaborate with other lab members generating NGS data. QUALIFICATIONS • Educational Background: Bachelor’s degree with at least one year of experience in epidemiology, computational biology, or bioinformatics. • Technical Skills: Proficiency in R or Python is required. Experience in microbiome bioinformatic processing is preferred. • Communication Skills: Ability to speak clearly and express oneself well in one-on-one conversations and groups. Develops effective written communications and uses them appropriately. Ability to present at weekly lab meetings using PowerPoint or other presentation programs. • Interpersonal Skills: Interacts and proactively shares information with internal and external contacts where appropriate. Develops effective professional relationships with peers, students, and employees. • Responsibility and Problem-Solving: Assumes responsibility to ensure issues/concerns are addressed and monitors them through to conclusion. Identifies, defines, and analyzes information and situations before recommending a course of action. • Time Management: Effectively manages own time and resources. • Innovation and Technology: Seeks to apply technology and innovation to improve efficiency and solve problems related to the goals of the research group. Minimum Salary Range USD $58,500.00/Yr. Maximum Salary Range USD $65,000.00/Yr.
Senior Expert Bioinformatics
Senior Bioinformatics Expert/Scientist within the Quantitative Science and Statistics group. Working in a highly collaborative environment, the successful candidate will build and develop bioinformatics support to next generation sequencing (NGS) technologies and platforms in advancing cell and gene therapy platform. The successful candidate is expected to play an active role in leading and managing bioinformatics initiatives and work in close collaboration with wet lab scientists and internal and external collaborators.Key Responsibilities:Work as a lead bioinformatics scientist both independently and as a member of cross-functional teams to lead the effort on NGS experimental design, data analysis and interpretation.Develop bioinformatics pipelines for NGS data analysis, data management and enabling data analysis pipelines in routine analysis. Provide troubleshooting and maintenance supports.Produce high quality written documentation including study protocols, data analysis plans and reports.Refine algorithms and tools for sequencing data analysis and propose improvements.Communicating internally with other departments and externally with collaborators about technological capabilities and gap analysis.Lead bioinformatics pipeline validation and transfer.Support the wider R&D team with general bioinformatics needEssential Requirements:PhD in bioinformatics, computational biology, biostatistics, molecular biology, virology or related discipline.At least 5 years of relevant industry work experience is required.Strong domain knowledge in genomics, excellent programming skills, and deep experience with next-generation sequencing and analysis.End-to-end complete life cycle experience in analysis and workflow/pipeline development for major NGS platforms for mutation analysis, genome mapping, variant calling and interpretation.Strong communication skills, ability to work both independently and collaboratively, to manage multiple concurrent, fast-paced projects and to work with multidisciplinary teams.Ability to set up bioinformatics computation systems from ground up.Experience in virology or viral gene therapy and working experience in GxP environment is considered a plusThe pay range for this position at commencement of employment is expected to be between $144,000 and $216,000/year; however, while salary ranges are effective from 1/1/24 through 12/31/24, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-cultureBenefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewardsCommitment to Diversity & Inclusion: The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.